Abstract: The physiology of chondrocyte is summarized in matrix synthesis and degradation. The imbalance between the two seems to be the trigger for osteoarthritis. The end products of matrix degradation result in inflammation that will cause the release of interleukine-1 (IL-1) and tumor necrosis factor α (TNF α) by synovial cells. Non steroidal anti inflammatory drugs (NSAID) by reducing the inflammation may interfere at this level and reduce the release of ...
Abstract: Purpose: The pathogenesis of Rheumatoid Arthritis (RA) is not well understood. Looking for three mediators [Soluble Interleukine 2 Receptor (SIL2R), ß2 Microglobulin (ß2M) and Tumor Necrosis Factor α (TNF α)] in RA patients sera and synovial fluid (SF) may clear some aspects of it. Methods: The above named mediators were estimated in 72 RA patient sera and SF, 13 patient with osteoarthritis (as patient control) and 130 blood donor (as normal ...
Abstract: Purpose: Polymyositis (PM) is an inflammatory muscle disease, which has more overlap with scleroderma than other connective tissue diseases. The aim of this study is to compare the clinical, paraclinical and therapeutic response of polymyositis with polymyositis-scleroderma overlap syndrome. Methods: During the past 10 years we had 16 overlap syndromes and 40 primary polymyositis. All patients were classified by the American college of Rheumatology classification criteria. Ninety-seven items were checked in ...